Huiying Zhao
Huiying Zhao, PhD
Director of big data centre, Sun Yat-sen Memorial Hospital, Sun Yat-sen University
Email: Zhaohy8@mail.sysu.edu.cn
Professor of Medical Research centre, Sun Yat-sen Memorial Hospital, Sun Yat-sen University
Education:
PhD in Bioinformatics (Minor in Biostatistics), School of Informatics, Indiana University,
USA, Aug 2013
Employment:
2017-current 100 talented-plan Principal Investigator of Sun Yat-sen Memorial Hospital, Sun Yat-sen University; Director of Bigdata center of Sun Yat-sen Memorial Hospital
2015-2019 NHMRC Peter Doherty Biomedical Fellow, Institute of Health and Biomedical
Innovation, Queensland University of Technology, Australia
2013-2015 Research Officer, QIMR Berghofer Medical Research Institute, Australia
2009-2013 Research Assistant, School of Informatics, Indiana University, USA
Honors and Funding:
• Integrating single-cell data with genomics data in human brain to identify
genetic mechanisms of Parkinson’s disease. 2024-2029, PI, NSFC,
490,000 RMB
• Integrating multi-omics data with gene expression network in human brain to identify
genetic mechanisms of Parkinson’s disease and drug discovery study. 2020-2024, PI, NSFC,
520,000 RMB
• Application of genes related to comorbidity of epilepsy to predict genetic mutations
causing epilepsy. 2019-2021，PI, NSFC，210,000RMB
• Development and application of novel bioinformatics approaches to identify pathogenetic
mechanisms underlying migraine. NHMRC Peter Doherty Australian Biomedical
Fellowship, 2014-2018, Sole PI, AUD $309,436.
•Identifying genetic differences between monozygotic twin pairs discordant for migraine via whole genome sequencing. American Migraine Research Foundation, 2017-2018, Co-PI, $50,000
• National Key R&D Program of China, Investigating key technology for big data and
precision medicine study, 2019-2020, PI, NSFC
• Identify Genes Associated with ALS. Griffith University-Peking University Collaborative
Research Scheme, 2015 (PI, AUD 6, 500).
Editorial Responsibilities:
• 2018-current: Technical Committee of China Computer Federation
• Faculty of 1000 associate faculty member
• Program Committee member for 13th Pacific Rim International Conference on Artificial
Intelligence Gold Coast, Australia, Oct 2014.
• Peer Reviewer for Journals: BMC Bioinformatics, PLOS One, and Experimental Biology
and Medicine
• Editor Board of Human Genetics
Peer-reviewed Publications:
Google Scholar: http://scholar.google.com/citations?user=ei4g2_gAAAAJ
Dr Zhao has published >60 publications in high-profile journals including Genome Biology,
Nucleic Acids Res, and Bioinformatics. Her current research interests include integrating multi-omics data
of neurological diseases or cancers with deep learning methods to discover the underlying mechanisms of genetic diseases.
Book chapters:
1. Yang Y, Huiying Zhao, Wang J and Zhou Y*. Sequence-based prediction of RNA
binding proteins by fold recognition and binding affinity prediction. Methods in
Molecular Biology. (Protein Structure Prediction, 119-130).
Referred Articles:
1. Lin S, Zhang H, Qi M, Cooper D, Yang Y, Yang Y, Huiying Zhao*, Inferring the genetic relationship between brain imaging-derived phenotypes and risk of complex diseases by Mendelian randomization and genome-wide colocalization. Neuroimage, Volume 279, 1 October, 2023.
2. Xiu X, Zhang H, Xue A, Cooper D, Yan L, Yang Y, Yang Y, Huiying Zhao*, Genetic evidence for a causal relationship between type 2 diabetes and peripheral artery disease in both Europeans and East Asians. BMC Medicine Volume 20, 31, August, 2022, Pages 1-16.
3. Zhang H, Xiu X, Xue A, Yang Y, Yang Y, Huiying Zhao*，Mendelian randomization study revealed a population-specific putative causal effect of type 2 diabetes in risk of cataract. International Journal of epidemiology 2021 Volume 50, 6, December 2021, Pages 2024–2037.
4. Bailing Zhou#, Huiying Zhao#, F Yu, C Guo, X Dou, J Wang*, EVLncRNAs: a manually curated database for long non-coding RNAs validated by low throughput experiments. Nucleic Acids Research, 2018 4;46(D1): D100-D105.
5. Zhang H, Xiu X, Yang Y, Yang Y, Huiying Zhao*, Identification of putative causal relationships between type 2 diabetes and biomarkers in East Asians by Mendelian randomization, American Journal of Epidemiology 2022
6. He D, Fan C, Qi M, Yang Y, Davide N. Cooper, Huiying Zhao*，Prioritization of schizophrenia risk genes from GWAS results by integrating multi-omics data. Translational Psychiatry, 11, Article number: 175 (2021).
7. Fan C, Chen, C, Zhou, J, Wong, P, He, D, Huang Y, Wang, X, Ling T, Yang Y, Huiying Zhao*. Systematic analysis to identify transcriptome‑wide dysregulation of Alzheimer’s disease in genes and isoforms. Human Genetics （140）, pages 609–623 (2021)
8. Huiying Zhao, Yang Y, Hai Lin, Xinjun Zhang, Matthew Mort, David N. Cooper, Yunlong Liu, and Yaoqi Zhou. Discriminating disease-causing from neutral non-frame shifting micro-INDELs by support vector machines with integrated sequence- and structure-based features. Genome Biology. 2013; 14(3)
9. Huiying Zhao, Yang Y, Zhou Y. Structure-based prediction of RNA-binding domains and RNA-binding sites and application to structural genomics targets. Nucleic Acids Research. 2011 Apr; 39(8):3017-25.
10. Zhao Huiying*, Nyholt DR. Gene-based analyses reveal novel genetic overlap and allelic heterogeneity across five major psychiatric disorders. Hum Genet. 2017 Feb; 136(2):263-274.